For example, lets compare the costs of tadalafil (generic Cialis). 0.00167 0.98 2.5 mg Ambien, Oct 2022 4.5 mg Lamictal (off Celexa, off Xanax) 0.95 Valium Ambien, 1/4 to 1/2 of a 5 mg tablet. 23/9 3mg.., 27/9 0mg. This means that after you take one dose of amitriptyline, in a little while, it starts making nortriptyline. Failed taper.Damn 1/4 valium nuts again! To create 10mL of the new liquid: measure out 1mL of vodka into a container and add one entire crushed tablet up to 25mgai in strength. Try searching for what you seek or ask your own question. GoodRx works to make its website accessible to all, including those with disabilities. The use of drinks that contain alcohol while taking amitriptyline raises your risk of serious side effects, including extreme drowsiness. Depending on how your nervous system interacts with the drug, converting to tablets may require taking the tablets in in 3 to 4 divided doses per day. Do not stop taking this drug without talking with your doctor. Stephen Hawking, I merged your posts here, into the Amitryptyline tapering topic, 2022 May- continuing with limited activity on site, just something I need to do right now. To find out how this drug might interact with something else youre taking, talk with your doctor or pharmacist. Amitriptyline can increase the risk of suicidal thoughts and behavior, especially in children, adolescents, and young adults. This can cause your body to process drugs more slowly. If youre paying out of pocket for your medication, this tactic could save you money. WebAmitriptyline is available on prescription. Its not ideal to split a pill. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. You can take amitriptyline with or without food. Also, do not start taking amitriptyline if you stopped taking a MAOI in the last two weeks, unless told to do so by your doctor. But if your symptoms are severe, call 911 or go to the nearest emergency room right away. Lapsed. May I cut my 50 milligram tablets in half and take half a dose? Symptoms can include: Orthostatic hypotension (sudden drop in blood pressure when standing). If you dont see a score, ask your pharmacist. We do not endorse non-Cleveland Clinic products or services. Because of the extremely long elimination half-life of fluoxetine, the potential for interacting with other drugs remains for several weeks after its discontinuation. Idawmn I was put on Amitriptyline last December to help with IBS Its always best to talk with your pharmacist or doctor first, cautions Dr. Miller. Then stopped taking the medication when my legs jerked. This results in a rather flat serum concentration curve. Webamitriptyline 10 mg tablet. Amy is given for many things but you don't say what yours was for. What to do if you miss a dose: Take your dose as soon as you remember. So I want to take this time a little more dosage. Amitriptyline is demethylated in the liver to its primary active metabolite, nortriptyline. Notes about amitriptyline and nortriptyline, Amitriptyline's metabolite, nortriptyline, is an even stronger drug. [31] In the short term, however, nortriptyline may disturb sleep due to its activating effect. Withdrawal (if you suddenly stop taking this drug). Amitriptyline/chlordiazepoxide oral tablet may cause dizziness and drowsiness during the first few hours after you take it. or can i take same dose in the morning? Thank you in advance! If you have a history of glaucoma or increased eye pressure, your doctor will monitor you closely while youre taking this drug. Take your time to get off them or you will get side effects. Keep the following in mind when it comes to cutting pills in half: Its possible for people who are prescribed a higher dose pill and told to take half, to forget to do so. I could not take it during the day, it made me too sleepy. We comply with the HONcode standard for trustworthy health information. Experiencing tingling body wide, burning in the top of my head and jerking movements at night ever since. I was put on Amitriptyline lastDecember to help with IBS and insomnia at 10 mg. It is quite possible because the tablet was cut in half, the full dose went into the bloodstream all at once reducing it's effectiveness. June 2009 - September 2010 25mg Amitriptyline. These devices will help you properly cut a pill. Do not take an MAOI within two weeks of stopping amitriptyline, unless told to do so by your doctor. Stopping it suddenly may cause side effects such as nausea, headache, and tiredness. Yes, probably offlabel for some pain problems. Talk to your doctor about these side effects as there may be other meds that would work better for you. The two drugs overlap until the dose of amitriptyline is fully metabolized, which takes about 6 x 20-25 hours or 5-6.25 days, then the nortriptyline effects take over. This could result in dangerous side effects. It's just my opinion but don't think splitting the Amitriptyline is helping. You may need to show airport staff the pharmacy label for your medication. For people with a history of glaucoma or increased eye pressure: Taking this drug could increase the pressure in your eyes. Just been prescribed for my wife's, now-troubling, osteoarthritis. Dont store this drug in moist or damp areas, such as bathrooms. University of Illinois-Chicago, Drug Information Group. My doc wants me to take a course of steroids and I am not sure how this will effect my symptoms. Oh FFS I have a packet of amitriptyline in the cupboard. They're useful for neuropathic pain and depression if you take them regularly - so I'm told, but you can't get high from them. But there are better painkillers and antidepressants. anyway, I wanted to know if someone tried large doses (250+) of this drug, and how they felt. Click to expand While splitting pills may not be encouraged, there are definite and understandable reasons why its done. After about a month my hallucinations were crazy. Supps/VitsOmega 3; Chelated Magnesium; Prebiotics/Probiotics, Vit D3. Policy. Big Pharma has a lot to answer for. But the reality is that the slicing and dicing of medications happens and it happens a lot. to 2019-10; 50mg in 2019 November; attempted CT (very fast taper) in December 2019, reinstated within 2 weeks at 20mg; Start slow taper in June2020:2020-06: 18mg; 2020-08: 16.6mg; 2020-10: 15.9mg; 2020-10: 15.45mg; 2020-10: 15mg; 2020-11:15.45mg; 2020-11: 15mg; 2020-11: 14.5mg; 2020-12: 13.7mg; 2021-02-12: 13mg; 2021-03-05: 12.5mg; 2021-03-11: 12mg; 2021-04-16: 11.5mg; 2021-06-06: 11mg; 2021-10-03: 10.5mg; 2021-11-24: 10mg; 2021-12-23:9.5mg; 2022-01-19: 9mg; 2022-03-08: 8.5mg; 2022-03-29: 8mg; 2022-05-16: 7.5mg; 2022-06-14: 7mg; 2022-07-13: 6.5mg; 2022-08-21: 6mg; 2022-10-29: 6.3mg; 2022-11-29: 6mg; 2022-12-11: 5.5mg; 2022-12-18: 5mg; 2023-01-21: 4.5mg; 2023-02-17: 4mg, Supplements: Fish oil (1g); magnesium glycinate (800mg); melatonin (0.3mg, reduced from 0.6mg in 2022-06). Disclaimer: Our goal is to provide you with the most relevant and current information. 2016 february start tapering lyrica from 450 mg to 200 mg2016 october tapered 25 mg amitriptyline to 25mg2017 tapered lyrica from 200 mg to 100 mg2017 september tapered my last tablet of 25 mg amitriptyline to zero (horrible muscle pain started)2018 february tapered lyrica from 100 mg to 75 mg (my muscle pain got worse and I have a lot of nervepain in my arms and legs, sometimes all over musclepain and nerve pain and burning pain)2018 may reinstated 25 mg lyrica. Some people even go down to 2.5mg before they stop. Redo of quit smoking 9/28/2022. Examples of these drugs include: All possible dosages and drug forms may not be included here. Does anyone know where I can get Palexia tablets in the UK from. So it is okay to take them as needed? ?, They are not time release so halving is just halving dosage . Would this work or do I need to even more careful? Has anyone ever stayed on 5 mg and been just fine with it? It was thanks to a lovely lady on this forum named christine who advised me to take it earlier than what i was doing & to wake up at the same time each day. These drugs are often used to treat similar conditions. Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. Most antidepressant tablets are safe to split. Updose - 2Aug - 87.5mg. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, Amitriptyline may interact with other medications, Important considerations for taking amitriptyline, http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1e6d2c80-fbc8-444e-bdd3-6a91fe1b95bd, Common sweetener erythritol tied to higher risk of stroke and heart attack, Gout: How metabolic syndrome may increase the risk, A new therapeutic target for the prevention of heart failure due to aortic stenosis, Skipping breakfast and fasting may compromise the immune system. Cutting Amitriptyline back to 5 mg per night Follow Posted 6 years ago, 5 users are following. This person wanted was a sleeping tablet, this doctor has written on the box ""take one at night, as required"". with an SRNI!!!!!!!!!!!!!!!! The risk of death as a result of amitriptyline overdose depends on the type of treatment administered to the patient. Amitriptyline overdose can cause respiratory depression; a patient can stop breathing. Heart rhythm can also be affected, which could be fatal. I'm trying graded activity to get rid of my pain. Remember though, that you can only split medication tablets and only if they're scored. This drug should only be used if the potential benefit justifies the potential risk. I have heard that it is freely soluble in lipid/fat, hence my idea of using milk. Other uses are off-label. Why not take two 10mg tablets that will equal 20mg. Ask your doctor about changing your dose and/or schedule. Discuss any decisions about your medical care with a knowledgeable medical practitioner. You do not want the stresses of withdrawal to up your pain. For people who have urinary retention (difficulty emptying your bladder completely): Taking this drug can worsen urinary retention. Researchers found that uneven tablet splitting resulted in varying dosages of the split pill, ranging anywhere from 50% to 150% of appropriate levels. But IMO the dosage you are taking is perhaps doing nothing & that is why you are probably feeling the way you are. Never try to catch up by taking two doses at once. Whatever the reason, cutting tablets in half is common. One study found that almost 1 in 8 split pills were off by more than 20%. This can result in taking a double dose of medication. Egton Medical Information Systems Limited. (2019). When you taper amitriptyline, you reduce both these drugs -- but the amount of amitriptyline in your bloodstream will lower at a faster rate than the nortriptyline, amitriptyline continually producing nortriptyline all the while. This mark, or notch, offers assistance to make a clean cut usually to make two even halves. Dec 2016 Jerking has lessened. I also found weaning off amitriptyline fairly easy with few side effects but bodies have different reactions so best to follow your drs advice. 1/2 life is 18-44 hr: So, it should be gone in a matter of days. Hopefully, my friend, has only taken a few taqblets, odd nights, if so, my advice will be STOP TAKING THEM!!! Dr. Lynne Weixel answered. Learn more about holiday depression. Your doctor will have to write a prescription specifying how the drug is to be compounded. I thought OK what about cutting the 5mg will it still be effective? 98 had run in with Paxil, 2 tablets, 3 weeks taper, survived.2005..menopause? Please help me here, with my friend, had to have 2 weeks off work, and not travelling well. 2018 june updosing lyrica. Amitriptyline oral tablet is not available as a brand-name drug. Medications that fall in this category include: The right equipment is essential for splitting a pill. If you have a seizure while taking this drug, stop taking it and call your doctor right away. Advertising on our site helps support our mission. Guidance can also be found within the gobs of text on medication labels or patient package inserts. Can you say Hallelujah? Then add 9mL (18mL, 36mL) of water to the vodka to make the final liquid solution. I have been taking it for around 9 months. Nortriptyline has its own active metabolite, 10-hydroxynortriptyline, half-life of 8-10 hours (https://www.springerlink.com/index/P65310133707531P.pdf. I decided to cut in in half because I was having the best sleep I have had In about 5 years. Children younger than 15 years of ageUse and dose must be What to know about getting help for depression. Tips. The potential for this interaction occurring with other SSRIs must be considered. Ativan - two years everyday, off and on for many years, Feb 2016 - Up to 10 mg, March 2016 - 0.75 mg, May 2016 - 3 mg, May 1, 2018 - benzo free, Zolpidem - March 2016 - 15 mg, July 22, 2017 - 0 mg, Trazodone - Feb 2016 - 325 mg, Sept 2016 and current - 87.5 mg,Amitriptyline - July 2016 - 10 mg, June 2022 - 5 mg, Gabapentin - July 2016 - 1000 mg, May 2018 - 600 mg, current - 542 mg, A project of Allostatic Overload LLC. Many tablets will break unevenly or crumble if you cut them too small. I was prescribed 10mg as a start for severe pain so that I can just sleep at night.I was previously given a high dose of tramadol,but that knocked me out too much that I was fearful. Taking certain drugs with amitriptyline may cause serious side effects. Always speak with your doctor or pharmacist about dosages that are right for you. Remember though, that you can only split medication tablets and only if they're scored. Be careful w/ other drugs too. Pamelor), is metabolised by liver enzyme CYP2D6. Call your doctor right away if you have serious side effects. Examples of these drugs include: Using an MAOI with amitriptyline can lead to seizures or even death. I have been on 20mg for 18 months now which i take for IBS as well as insomnia & headaches i was experiencing which i am not now. This study indicates the stability of this amitriptyline suspension will be less than 21 days. Speak to a pharmacist. was wondering what might happen if i somehow split the dose to some at night and then some in the morning? I feel the ones I have left might have suffered in the light and I just can't risk worse nights right now! Examples include: Many cholesterol medications can also be cut in half. Yes, milk is a very good substitute for alcohol for making a liquid form of Amitriptyline. After 23 lost years. You should not take these drugs and amitriptyline at the same time. Amitriptyline oral tablet can interact with other medications, vitamins, or herbs you may be taking. 20 years on Paxil starting at 20mg and working up to 40mg. Seeking help for depression can be the first step to recovery. This raises your risk of side effects. I am curious to find out if any of you used milk for liquid tapering amitriptyline. Your doctor will write the number of refills authorized on your prescription. One month later I still have tingling and muscle jumps. 13Jul -212.5mg;6Aug -200.0mg;24Aug -187.5mg;13Sep -175.0mg;3Oct -162.5mg;26Oct -150mg, 20179Jan -150.00mg;23Mar -137.50mg;24Apr -125.00mg;31May -112.50mg holding; 3Sep -100.00mg;20Sep -93.75mg;20Oct - 87.5mg;12Nov - 81.25mg;13 Dec - 75.00mg. TBH the dosages you are on won't touch the sides as my grandma would say. Request permission for repost or publication. Do not worry about any sediment, that is just filler and does not count. For women who are breastfeeding: Amitriptyline passes into breast milk and may cause side effects in a child who is breastfed. I have some tablets of amitriptyline that have a coating. at the If theres no score line on a pill, consider it a STRONG message that its not meant to be split. All Rights Reserved. Amitryptiline, Prozac, bupropion, buspirone, flurazepam, diazepam, alprazolam, Paxil, citalopram, lamotrigine, gabapentinprobably more I've forgotten. Symptoms can include: If you develop these symptoms, call 911 or go to the nearest emergency room. Not perfect, but much better. He makes it seem as if the withdrawal will be bad and scary. If you have this condition, let your doctor know before starting this drug. Amitriptyline hydrochloride is soluble 1:1 in water.11 The USP and the Ph. can amitriptyline hcl 10mg be cut in half? A common question that many people ask their pharmacists is, can I split my pills? Theres a variety of reasons people want to split their pills. Drug Interactions [see the page for full list]. Amitriptyline is used to help relieve symptoms of depression. Feb 1996 ct tegretol, tapered Zoloft 8 weeks. Select one or more newsletters to continue. However, the dose is usually not more than 150 mg per day, unless you are in the hospital. Is it okay to cut these pills if they are not scored? If you stop taking this medication suddenly you may have withdrawal side effects such as nausea, headache, and tiredness. 2016Withdrawal research. Some modified-release tablets also have a special coating on the outside. 5 users are following. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. Well, its tougher than you might think. Look at your tablet. A project of Allostatic Overload LLC. I have been on them for 4 yrs and not put on weight. This drug should not be used in people with bipolar disorder. Taking amitriptyline with certain drugs raises your risk of negative effects. Even with GoodRx coupons, getting more pills of the lower strength is less costly. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. WebA US doctor answered Learn more. Been put onto this funny old stuff for nerve pain. Look on the package and check with the manufacturer. To help avoid interactions, your doctor should manage all of your medications carefully. 5/28/2015-off Adderal salts 2.5mg. New Prep Is Easier to Swallow, What to Know About Over-the-Counter Sleep Aids, 8 Jobs That Lead to Hearing Loss and How to Prevent It, 6 Sore Throat Remedies That Actually Work. No real side effects are expected coming off of 10 mg of amitriptyline but you could cut the 10 mg pill in calf and use that for 3-5 days. All rights reserved. Took anti inflamitories for a couple of weeks Nov 2016. Bupropion hydrochloride ER oral tablets are generic drugs used to treat certain types of depression. Call 911 if your symptoms feel life threatening or if you think youre having a medical emergency. Maybe some people have high anxiety and so panic thinking they will never cope with the withdrawal. If your doctor prescribes liquid and tablets or capsules at the same time, most likely he or she will have to indicate "divided doses" in the prescriptions to get the drugs covered by insurance. I know the latest tip from SurvivingAntidepressants is to use alcohol for liquid tapering of amitriptyline. 7 May - usual depression questionnaire gives "probably no depression" result. You should take longer to come off your amitriptyline as you are on 25mg and you need to cut down gradually. Protect every disabled person from welfare cuts. If youre filling your prescriptions through an insurance plan, splitting pills may not make a difference in the cost of your medications. [clarification needed] Nortriptyline may also have a sleep-improving effect due to antagonism of the H1 and 5-HT2A receptors. Harm reduction: Taper by 10% As with other psychiatric drugs, a conservative taper of 10% per month, calculated on the last dosage (the amount of the decreases keeps getting smaller), is recommended to minimize withdrawal symptoms. Dont take this drug again if youve ever had an allergic reaction to it. You may need to decide whether to stop breastfeeding or stop taking this medication. They can tell you if cutting your pill is safe. Doing a very slow microtaper, down to low doses now and feeling SO much better, getting my old personality and my brain back! Cleveland Clinic 1995-2023. Serotonin syndrome, oh yes! Only split your pills once unless directed otherwise on your prescription label. A score line might indicate a pill can be split, but it doesnt mean that you should.. A 2.5% taper every week may be more comfortable in these situations -- by continually reducing both amitriptyline and nortriptyline, you might stay ahead of any adverse nortriptyline effect. There may be ways to get the proper dosage into one pill that works, which is preferred., Cleveland Clinic is a non-profit academic medical center. Sept 2011 started 10% every 6 weeks taper (2.5% every week for 4 weeks then hold for 2 additional weeks), currently at 7.9mg. If you've been on this drug for more than a month, we recommend a much slower taper, see http://survivingantidepressants.org/index.php?/topic/1024-why-taper-by-10-of-my-dosage/. You usually end up with pieces unless you have a actual pill cutter which still does not cut then in half.With all the difference sizes available why would you want to cut it in half?Make sure you take it with some food if you do try it. Updose - 27Aug - 100.0mg. The liquid also comes in 3 different strengths containing 10mg, 25mg or 50mg of amitriptyline in a 5ml spoonful. This drug can cause a severe allergic reaction. I was like a zombie all day so i was cut back to 25..years later, I cut it down myself to 10 mm dont ask me why, lol, then 5 but, unfortunately it was not doing anything at all, so to cut a long story, short ive been on 25 for the last 20 years, i only take it at night, about 6. I find that works for me. I was told to take one tablet per night to help me sleep. This division continues until there is an untraceable But dont just assume its safe to split any pill with a score mark. 6 years ago,
For precise dosing, weigh the pieces with a digital scale. By providing your email address, you agree to receive emails containing coupons, refill reminders and promotional messages from GoodRx. Dont put this medication in your cars glove compartment or leave it in the car. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Amitriptyline can cause dizziness and drowsiness during the first few hours after you take it. Can I cut meloxicam 15 in half and take half in morning and half at night? Amitriptyline contains a half-life of approximately 20 hours.
I take amitriptyline and I have learned through trial and error to take the dose 10 or 11 hours before I want to get up in the morning to avoid that groggy feeling in the morning. So, if youre going to do it, follow this advice: Ask before you make a cut and take safety steps to do it properly, advises pharmacist Alison Miller, PharmD. report this API to be freely soluble in water. This information is for informational purposes only and is not meant to be a substitute for professional medical advice, diagnosis or treatment. The average retail cost of thirty 5 mg tablets is about $300. Updose - 11Oct 112.5mg. Be sure to tell your doctor about all medications, vitamins, or herbs youre taking. Take exactly as your doctor has prescribed. If you see a score line, it should be safe to split it along that line. Always discuss possible side effects with a healthcare professional who knows your medical history. If you stop taking the drug suddenly or dont take it at all: If you dont take amitriptyline, your depression may worsen. Amitriptyline can also cause other side effects. Otherwise, I will be back here for advice.. Alto, you are a lifesaver! Question posted by beckymcg on 14 July 2013, Last updated on 7 January 2022 by Deuce2022. How to tell if the drug is working: Over time you should notice an improvement in your symptoms of depression. I hope you are not one of them who thinks that way. This will yield 10mL (20mL, 40mL) of solution that will have the strength of the original tablet so you can calculate the volume of your dose from there. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Counting out pellets (sustained-release amitriptyline capsules). For those of you that have taken Amitriptyline, what dose did you jump off at and what method did you use? A score is the No. GoodRx is not sponsored by or affiliated with any of the third-party brands identified. However, there are a number of capsules that you are allowed to open and sprinkle on soft foods, such as applesauce. This can make a medication less effective or raise the risk of side effects. Amitriptyline is used to treat symptoms of depression. GoodRx provides no warranty for any information. and Privacy Policy and steps will be taken to remove posts identified
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You can then cut up the tablets to reduce the daily dosage. It isn't scored because its not supposed to be cut. Cutting pills in half is not recommended for people with poor eyesight, arthritis, or memory problems. Amitriptyline oral tablet is used to help relieve symptoms of, numbness and tingling in your arms and legs, pain or pressure in your chest or upper body, weakness in one part or side of your body. Got sicker and sicker, but believed I needed the drugs for my "underlying disease". August 16, 2011 in Tapering, Aka Vanatrip, Elavil, Endep, Saroten Retard, Official FDA information at http://www.drugs.com/pro/amitriptyline.html, Amitriptyline is a tricyclic antidepressants (TCA). Learn about dosage, side effects, uses, and more. -- Albert Einstein. Dont split pills in advance. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. If theyre more severe or dont go away, talk with your doctor or pharmacist. at the longest, 10mg would be 5mg in 2 days, 2-1/2mg in another 2, 1 in another 2 - you're good to go! I assume its okay because thats what my dr said to do but i just wanted to get others opinions. To be on the safe side, replace it within 2 weeks. (took me long enough), None of my posts are intended as medical advice. Amitriptyline is very soluble (25mgai/1mL) in ethanol, commonly found in vodka. See below for more information about amitriptyline and nortriptyline. Its best to buy a pill splitter if you take oral medications on a regular basis. I don't know anyone who's done this. Amitriptyline as such is rapidly absorbed but owing to the sustained release from SAROTEN RETARD capsules amitriptyline only becomes available for absorption slowly. You should not need a new prescription for this medication to be refilled. Always speak to your doctor before acting and in cases of emergency seek
Serious side effects of amitriptyline oral tablets that have been reported include: heart problems, such as: abnormal heart rhythm heart attack increases or We comply with the HONcode standard for trustworthy health information. Good idea, you mean the sunlight hash't damaged them yet? To view profiles and participate in discussions please. Patient is a UK registered trade mark. 1April - 162.5mg. Insomnia slowly getting better, still in need of help on 2 out of 7 days. But you need to ask so they can double check for you. All rights reserved. Use of this drug in children must balance the potential risks with the clinical need. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. How difficult can it be to evenly split a pill in half? So, I know I've got to be a bit careful with this stuff and what I read here confirms that. If you get an adverse effect 5-7 days after you reduce amitriptyline, it may be the effect of the nortriptyline, not a withdrawal symptom. Last medically reviewed on August 7, 2022. The most common example of this is an extended-release (ER or XR) tablet. Eur. This information is not a substitute for medical advice. Color: blue Shape: round Imprint: 2101 V. This medicine is a brown, round, film-coated, tablet imprinted with "MP 26". My advice would be to go back to your GP, explain your symptoms & take it from there. Amitriptyline is a tricyclic antidepressants (TCA). Try searching for what you seek or ask your own question. This is perhaps because you have taken yourself off your amitriptyline. Reinstated, 6mg, then 12mg. LIGHTBULB MOMENT, I have MTHFR 2x mutations. OMG. Your doctor will monitor your mental health while you take this drug. Your gp is covering himself by saying cut tablet in half.